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Indications

Prednisone is indicated to treat primary or secondary adrenal cortex insufficiency (lack of sufficient adrenal hormone in the body).
Prednisone is indicated to reduce inflammation and alleviate symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma.
Prednisone is a steroid drug.

Prednisone is indicated in treating all of the following:
- trichinosis (with complications);
- thyroid gland inflammation;
- skin diseases;
- severe flare-ups of ulcerative colitis or enteritis (inflammation of the intestines);
- rheumatoid arthritis and related disorders;
- prevention of organ rejection;
- meningitis (inflamed membranes around the brain);
- lung diseases, including tuberculosis;
- fluid retention due to "nephrotic syndrome" (a condition in which damage to the kidneys causes protein to be lost in the urine);
- flare-ups of multiple sclerosis;
- eye diseases of various kinds;
- diseases of the connective tissue including systemic lupus erythematosus;
- certain cancers (along with other drugs);
- blood disorders;
- allergic conditions (severe);
- abnormal adrenal gland development;

Side Effects

Prednisone side effects that you should report to your health care professional or doctor as soon as possible:
- Bone fractures;
- Bruising;
- Bulging eyes;
- Congestive heart failure;
- Convulsions;
- Distended abdomen;
- Euphoria;
- Face redness;
- Fluid retention high blood pressure;
- Fragile skin;
- Glaucoma;
- Headache;
- Hives and other allergic-type reactions;
- Increased pressure inside eyes or skull;
- Inflamed esophagus or pancreas;
- Insomnia;
- Irregular menstrual periods;
- Mood changes;
- Muscle weakness or disease;
- Osteoporosis;
- Peptic ulcer;
- Personality changes;
- Poor healing of wounds;
- Psychotic behavior;
- Severe depression;
- Stunted growth (in children);
- Sweating;
- Thin;
- Vertigo;

Contraindications

Prednisone is contraindicated if you have any of the following conditions:
- diverticulitis or other disorder of the intestine;
- high blood pressure;
- if you have a body-wide fungus infection;
- if you have an eye infection caused by the herpes simplex virus;
- if you have an underactive thyroid gland or cirrhosis of the liver;
- if you have ever had an allergic reaction to Prednisone;
- if you have inactive tb and must take Prednisone for an extended time;
- kidney disorder;
- myasthenia gravis (a muscle-weakness disorder);
- osteoporosis (brittle bones);
- peptic ulcer;
- ulcerative colitis (inflammation of the bowel);

Interactions

Do not take Prednisone with any of the following drugs:
- troleandomycin (tao);
- rifampin (rifadin);
- potent diuretics such as lasix;
- phenytoin (dilantin);
- phenobarbital (donnatal, others);
- oral contraceptives;
- ketoconazole (nizoral);
- estrogen drugs such as premarin;
- carbamazepine (tegretol);
- blood thinners such as coumadin;
- amphotericin b (fungizone);

Dosage

Typical starting doses can range from 5 mg to 60 mg a day.

Dosage is determined by the condition being treated and your response to the drug.

For treatment of acute attacks of multiple sclerosis, doses of as much as 200 mg per day may be given for a week, followed by 80 mg every other day for a month.

Once you respond to the drug, your doctor will lower the dose gradually to the minimum effective amount.

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